Presentation
Mind the Difference: Pharmacotherapy Variability in Neurocritical Care and Precision Medicine
DescriptionNeurological and medical complications in neurocritical care contribute significantly to the overall disease prognosis. Pharmacological management plays a key role in managing complications such as cerebral vasospasm, delayed cerebral ischemia (DCI), hyponatremia, infections, and seizures. However, pathophysiologic changes induced the neurological illness make the medical management of these patients challenging. To illustrate, significant research efforts have been dedicated to understanding the mechanisms of DCI and investigating potential therapeutic modalities to enhance patient outcomes in subarachnoid hemorrhage patients. Several agents have been investigated to target DCI; however, none of those agents was proven effective with the exception of nimodipine. This has been attributed, at least in part, to the inter-individual variability in disease pathophysiology. Moreover, altered organ function, systemic inflammation, hemodynamic instability, and common interventions employed in intensive care settings have the ability to alter the pharmacokinetics and pharmacodynamics of medications. Neurocritical care patients endure numerous physiologic insults following a primary neurologic injury that can result in increased mortality, hospital length of stay and poor neurological outcomes. The use of potentially ineffective treatments and suboptimal dosing of medications to manage patients may inflate poor outcomes as the understanding of the influence of neurological injury on the action and disposition of drugs is ill defined.
The suggested session will provide an overview of the current research in this field, elucidate the factors that contribute to pharmacotherapy variability, and outline potential future research directions in this area.
The suggested session will provide an overview of the current research in this field, elucidate the factors that contribute to pharmacotherapy variability, and outline potential future research directions in this area.
Speaker
Event Type
Breakout Session
TimeWednesday, October 16th10:05am - 10:25am PDT
LocationHarbor Ballrooms D-I
Science of Neurocritical Care
Basic/Neurocritical Care 101
General Critical Care
Intracerebral Hemorrhage
Multimodal Neuromonitoring (invasive/non-invasive)
Nursing Pharmacology
Pharmacist Practice
Stroke
Subarachnoid Hemorrhage
Traumatic Brain Injury
Intermediate