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BEGIN:VEVENT
DTSTAMP:20241017T183511Z
LOCATION:Harbor Ballrooms D-I
DTSTART;TZID=America/Los_Angeles:20241016T100500
DTEND;TZID=America/Los_Angeles:20241016T102500
UID:ncs_NCS 2024_sess117_ccrnt154@linklings.com
SUMMARY:Mind the Difference: Pharmacotherapy Variability in Neurocritical 
 Care and Precision Medicine
DESCRIPTION:Breakout Session\n\nSherif Hanafy Mahmoud (University of Alber
 ta)\n\nNeurological and medical complications in neurocritical care contri
 bute significantly to the overall disease prognosis. Pharmacological manag
 ement plays a key role in managing complications such as cerebral vasospas
 m, delayed cerebral ischemia (DCI), hyponatremia, infections, and seizures
 . However, pathophysiologic changes induced the neurological illness  make
  the medical management of these patients challenging. To illustrate, sign
 ificant research efforts have been dedicated to understanding the mechanis
 ms of DCI and investigating potential therapeutic modalities to enhance pa
 tient outcomes in subarachnoid hemorrhage patients. Several agents have be
 en investigated to target DCI; however, none of those agents was proven ef
 fective with the exception of nimodipine. This has been attributed, at lea
 st in part, to the inter-individual variability in disease pathophysiology
 . Moreover, altered organ function, systemic inflammation, hemodynamic ins
 tability, and common interventions employed in intensive care settings hav
 e the ability to alter the pharmacokinetics and pharmacodynamics of medica
 tions. Neurocritical care patients endure numerous physiologic insults fol
 lowing a primary neurologic injury that can result in increased mortality,
  hospital length of stay and poor neurological outcomes. The use of potent
 ially ineffective treatments and suboptimal dosing of medications to manag
 e patients may inflate poor outcomes as the understanding of the influence
  of neurological injury on the action and disposition of drugs is ill defi
 ned.\nThe suggested session will provide an overview of the current resear
 ch in this field, elucidate the factors that contribute to pharmacotherapy
  variability, and outline potential future research directions in this are
 a.\n\nTrack: Science of Neurocritical Care\n\nFocus Area: Basic/Neurocriti
 cal Care 101, General Critical Care, Intracerebral Hemorrhage, Multimodal 
 Neuromonitoring (invasive/non-invasive), Nursing Pharmacology, Pharmacist 
 Practice, Stroke, Subarachnoid Hemorrhage, Traumatic Brain Injury\n\nTarge
 t Audience: Intermediate\n\nSession Chair: Sherif Mahmoud (University of A
 lberta, School of Public Health)
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